Dr Andy Stein

Chronic kidney disease: pathophysiology and progression

Chronic kidney disease: pathophysiology and progression This article is primarily for health professionals. Pathophysiology Unlike acute kidney injury (AKI), where the healing process is complete with complete functional kidney recovery, chronic and sustained insults from chronic and progressive nephropathies evolve to progressive kidney fibrosis and destruction of the normal architecture of the kidney. This affects […]

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New drug candidate shrinks kidney cysts in polycystic kidney disease (PKD)

New drug candidate shrinks kidney cysts in polycystic kidney disease (PKD) In a recent study on animals and cells by Fedeles, 2024, a compound originally developed as a cancer treatment, was shown to hold promise for patients with autosomal dominant polycystic kidney disease (ADPKD). The kidneys in PKD can become very big Why is this

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Can my GFR get better?

Can my GFR get better? Yes. It does not always ‘progress’ (worsen) from a ‘better stage’ (e.g. CKD1-2) to a ‘bad stage’ (CKD5, kidney failure). Sometimes it gets better, and you return to normal kidney function. When looking at your eGFR results, a higher number is better. In general, an eGFR value lower than 60 ml/min

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